Biochem/physiol Actions

Reversible: no

Target K_i: 760 pM against caspase-1

Product does not compete with ATP.

Primary Targetcaspase-1

Cell permeable: yes

General description

Interleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. Caspase-1 inhibitor II is a cell-permeable, irreversible inhibitor of Caspase-1, Caspase-4, and Caspase-5. Inhibits CPP32/Apopain at a much higher concentration. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.

A cell-permeable and irreversible inhibitor of caspase-1 (K_i = 760 pM), caspase-4, and caspase-5. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Brenner, B., et al. 1998. Cell Death Differ. 5, 29.Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.Schlegel, J., et al. 1996. J. Biol. Chem.271, 1841.Enari, M., et al. 1995. Nature375, 78.Walker, N.P.C., et al. 1994. Cell78, 343.Thornberry, N., et al. 1992. Nature356, 768.

Packaging

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sequence

Ac-Tyr-Val-Ala-Asp-CMK

Warning

Toxicity: Standard Handling (A)